Dr. Lisa N. Gentile
Associate Professor of Chemistry Speciality:
Chair, Chemistry
C-308 Gottwald Center for the Sciences
Office: (804) 484-1578
Fax: (804) 287-1897
http://facultystaff.richmond.edu/~lgentile/
Biophysical Chemistry
Teaching:
Protein, Structure, Function & Biophysics Lecture & Lab
Research:
In general, what I am most fascinated by is protein structure. More specifically, how that structure dictates function and biomolecular recognition, and what happens when that structure is altered in diseased states. The techniques that my group uses to monitor and determine protein structure are circular dichroism (CD), fluorescence, and nuclear magnetic resonance (NMR) spectroscopy. Students working in my lab are involved in the production of protein (cloning, mutagenesis, over-expression), its purification, and its biophysical characterization. I encourage interested students to come and talk with me.
Education:
Ph.D., Brown University
Selected Publications:
*Raabe, R.; and Gentile, L.N." Antidepressant interactions with the NMDA NR1-1b subunit." Journal of Biophysics, Article ID 474205, 8 pages, 2008. doi:10.1155/2008/474205.
*Raabe, R.; and Gentile, L.N. "Thermal and chemical denaturation of Bacillus circulans xylanase: a biophysical chemistry laboratory module," Biochemistry and Molecular Biology Education, 36, 6, 428 (2008).
Hoke, K, and Gentile, L.N. "Early involvement in undergraduate research at the University of Richmond," CUR Quarterly, 29. 1, 18 (2008).
*Jeppesen, B.; *Costello, L.; *Fung, A.; *Stanley, E.; *McDonald, J.; *Lambert, A.; *Johnson, B.; and Gentile, L.N. "Structure nor stability of the transmembrane spanning 6/7 domain of Presenilin I correlates with pathogenicity." Biochemical and Biophysical Research Communications, 2007, 355, 820.
*Stoll, L.; *Seguin, S.; and Gentile, L.N. "Tricyclic antidepressents, but not the selective serotonin reuptake inhibitor fluoxetine, bind to the SIS2 domain of ionotropic glutamate receptors." Archives of Biochemistry and Biophysics, 2007, 458, 213.
*Stoll, L.; *Hall, J.; *Van Buren, N.; *Hall, A.; *Knight, l.; *Morgan, A.; *Zuger, S.; *Van Deusen, H.; and Gentile, L. "Differential regulation of ionotropic glutamate receptors." Biophysical Journal, 2007, 92, 1343.
Russo, S.; and Gentile, L.N. "Preparation, purification, and secondary structure determination of Bacillus circulans xylanase: a laboratory module incorporating aspects of molecular biology, biochemistry, and biophysical chemistry." Journal of Chemical Education, 2006, 83, 1850.
*Stoll, L.; and Gentile, L.N. "Linking tricyclic antidepressents to ionotropic glutamate receptors." Biochemical and Biophysical Research Communications, 2005, 333, 322.
*Spivak, V.; *Lin, A.; *Beebe, P.; *Stoll, L.; and Gentile, L.N. "Identification of a neurosteroid binding site contained within the GluR2-S1S2 domain." Lipids, 2004, 39, 811.