Dr. Joseph Gindhart

Associate Professor of Biology
B-214 Gottwald Science Center
Office: (804) 287-6892
Fax: (804) 289-8233

Research:
Understanding how the microtubule motor kinesin recognizes and transports its intracellular cargoes. Kinesin is part of a large superfamily of proteins required for chromosome movement, organelle transport, mRNA localization, and the positioning of cellular compartments. Projects in my laboratory use genetic, biochemical, and molecular approaches to identify and characterize novel proteins that can bind to kinesin, and then test the in vivo relevance of observed interactions.

Selected Publications:

Gindhart, Jr., J.G. (2006) Towards an understanding of kinesin-I dependent transport pathways through the study of protein-protein interactions. Briefings in Functional Genomics and Proteomics, February 23.

Weite, M.A., Cermelli, S., Griner, J., Viera, A., Guo, Y., Kim, D., Gindhart, Jr., J.G., & Gross, S.P. (2005) Regulation of lipid-droplet transport by the perilipin homolog LSD2. Current Biology, v. 15, 1266-1275.

Wisniewski, T.P., Tanzi, C.L., & Gindhart, Jr., J.G. (2003) The drosophila kinesin-I associated protein YETI binds both kinesin subunits. Biology of the Cell, 95, 595-602.

Gindhart, Jr., J.G., Chen, J., Faulkner, M., Gandhi, R., Doerner, K., Wisniewski, T., & Nandlestadt, A. (2003) The Kinesin-associated Protein UNC-76 is required for axonal transport in the drosophila nervous system. Molecular Biology of the Cell, v.14, issue 8, 3356-3365.